NeuroCuple® Technology, Patents & Clinical Evidence

NeuroCuple® is built on patented nanocapacitive technology designed to provide drug-free, reusable pain relief without batteries, wires, or medication. This page brings together how the technology works, the patents that protect it, and the published clinical research behind it — in one place.

How NeuroCuple® Technology Works

NeuroCuple® is a passive nanocapacitive platform — it doesn't rely on an external power source, battery, or electrical stimulation. Instead, it's built from layered materials designed to interact with the body's natural bioelectrical environment near the area where it's placed. The technology is incorporated into lightweight, reusable devices that can be worn during normal daily activity.

Because the device is passive, it doesn't produce heat, vibration, or a noticeable sensation the way a heating pad or TENS unit would. It's designed to support the body's own processes rather than mask discomfort with an external stimulus — which is also why it can be reused indefinitely rather than discarded after one use.

Patent Portfolio

The NeuroCuple® patent portfolio covers the materials, structures, manufacturing methods, and techniques used to build the device — protecting a specific, non-invasive approach to pain relief that doesn't rely on drugs, batteries, electrical stimulation, heating elements, or consumable components.

2020
U.S. Patent No. 10,707,570
Foundational NeuroCuple® architecture — covers the system's layered construction and interaction with biologically-generated AC signals.
2022
U.S. Patent No. 11,380,985
Advanced multilayer nanostructures that disrupt pain signals noninvasively, supporting reusable, drug-free relief with zero consumables.
2024
U.S. Patent No. 11,967,761
Enhanced material designs that interact with localized energy fields to reduce pain without external power or heat.
2026
U.S. Patent No. 12,646,830
Expanded system designs and methods, broadening the portfolio to additional materials, configurations, and applications in pain management, recovery, and rehabilitation.

Together, these patents form the foundation of NeuroCuple® technology and help ensure long-term product quality, consistency, and continued development. NeuroCuple® technology was invented by Rhett F. Spencer and has evolved through multiple generations of research, development, and patent protection.

Clinical Research & Evidence

NeuroCuple® has been evaluated in published clinical research, including a randomized, placebo-controlled trial and an earlier open-label pilot study. This evidence supports controlled evaluation and clinical discussion — it does not support replacing standard medical care or medication decisions made with your doctor.

Randomized, Sham-Controlled Trial (2026)

Klatt et al., The Journal of Arthroplasty University of Pittsburgh Medical Center Shadyside & UPMC East · n = 156 · NCT06460350 · NIDA/NIH funded
26%
Less opioid use in the first 24 hours after surgery (P = 0.015)
19%
Shorter hospital length of stay (P = 0.006)
14%
Less pain at rest at week 1 (P = 0.05)

The trial also found fewer episodes of postoperative nausea and vomiting and less rescue antiemetic use in the active-device group, though these trends did not reach statistical significance at this study's size. No serious device-related adverse events were reported; device-related effects (skin irritation, discomfort, compression) were mild and resolved with adjustment or removal.

Open-Label Pilot Study (2023)

Chelly et al., Journal of Clinical Medicine UPMC Shadyside Hospital · n = 69 · NCT05252858
41%
Reduction in pain at rest (AUC, POD 1–30 vs. control)
34%
Reduction in pain with movement (AUC, POD 1–3 vs. control)
52%
Fewer opioid refills (POD 3–30 vs. control)

This earlier pilot study helped motivate the larger, randomized, placebo-controlled trial above. Together, the two studies represent a growing body of evidence — from an initial open-label signal to a confirmatory, blinded, sham-controlled trial.

The Story Behind NeuroCuple®

NeuroCuple® technology was invented by Rhett F. Spencer, and has been developed over multiple generations of research and patent protection. Read more about the founder's story and how NeuroCuple® came to be →